A Canterbury tale

Digital Necrosis: A Hoarder’s Tale

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

The Canterbury Tales and cardiology.

Herrick revealed his broad interest in medicine in 1910 when he reported the "Peculiar Elongated and Sickle-Shaped Red Blood Corpuscles in a Case of Severe Anemia."3 He, therefore, earned for himself the distinction of recognizing and describing two clinically important disorders: obstruction of coronary arteries without sudden death and sickle cell disease. He showed us his love of history and...

A Tale of Histories

Constraint Handling Rules (CHR) is an elegant, high-level programming language based on multi-headed, forward chaining rules. A distinguishing feature of CHR are propagation rules. To avoid trivial non-termination, CHR implementations ensure a CHR rule is applied at most once with the same combination of constraints by maintaining a so-called propagation history. The performance impact of this ...

A tell tale handshake

Myotonic dystrophy is a group of inherited disorders called muscular dystrophies. Clinical presentation of this disease is characterised by progressive muscle weakness with myotonia, cataracts, infertility (in males) and cardiac conduction defects. We present a case of a 35 year old male with lung abscess, later diagnosed to be a case of myotonic dystrophy. Lung abscess is an uncommon presentat...